What are imidazole derivatives?

What are imidazole derivatives?

Many imidazole-based derivatives have been marketed as antifungal drugs such as ketoconazole (1), miconazole (2), clotrimazole (3), tioconazole (4), econazole (5), tinidazole (6), enilconazole/imazalil (7), parconazole (8), eberconazole (9), lanoconazole (10), fenticonazole (11), bifonazole (12), sulconazole (13).

Is imidazole a carboxylic acid derivative?

Imidazole-4-Carboxylic Acid.

What drug contains imidazole nucleus?

Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. For comparison, another group of azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole.

What are imidazole drugs?

Azoles. Among the azole group of antifungal medications, imidazoles (miconazole and ketoconazole) are commonly used for localized surface infections and triazoles (itraconazole—for dermatophytes only—fluconazole, voriconazole, and posaconazole) are used for invasive, life-threatening fungal infections.

What is the structure of imidazole?

C3H4N2
Imidazole/Formula

How do you synthesis imidazole?

A ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes provides 2,4(5)-disubstituted imidazoles in good yields. A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation-condensation protocol, followed by bromination and Suzuki coupling.

What is pyridine derivatives?

The important pyridine derivatives include niacin, nicotinamide, isonicotinoylhydrazine, nicotine, strychnine, and vitamin B6. Miscible with water, alcohols, ethers, petroleum ether, oils, benzene, chloroform and most of other organic solvents, pyridine is an important chemical raw materials and solvents.

Which is the imidazole antifungal?

Ketoconazole topical (Nizoral) Ketoconazole is an imidazole broad-spectrum antifungal agent; it inhibits the synthesis of ergosterol, causing cellular components to leak, resulting in death of fungal cells.

What is not imidazole antifungal?

Of the clinically employed azole antifungals, only a handful are used systemically. These include ketoconazole, itraconazole, fluconazole, fosfluconazole, voriconazole, posaconazole, and isavuconazole. Examples of non-azole systemic antifungals include griseofulvin and terbinafine.

Which of the following is imidazole antifungal?