Why wet granulation is not suitable?
Why wet granulation is not suitable?
The cost of wet granulation is higher because of the time, labour, energy, equipment and space required for the process. 3. The process is not suitable for thermolabile and moisture-sensitive materials.
What are the advantages and disadvantages of wet granulation?
1 Introduction
| Wet granulation | Dry granulation | |
|---|---|---|
| Disadvantages | • Not suitable for moisture sensitive products • Time consuming because of involvement of additional unit operation of drying | • High force involved in compaction • Greater chances of generation of dust and environmental contamination |
What are the advantages and disadvantages of granules?
Advantages and Disadvantages of granules Advantages • Granules are more flowable compared to powder. Segregation of the constituents of the powder mixture could be avoided by granulation. Granules are more stable against humidity and atmosphere. Granules are more easily wetted by liquids than light and fluffy powders.
What are problems of granulation?
Nevertheless, granulation poses numerous challenges due to high quality requirement of the formed granules in terms of content uniformity and physicochemical properties such as granule size, bulk density, porosity, hardness, moisture, compressibility, etc. together with physical and chemical stability of the drug.
What is the purpose of wet granulation?
In wet granulation processes, the powder particles are aggregated through the use of a liquid phase called binder. The main purposes of size-enlargement process of a powder or mixture of powders are to improve technological properties and/or to realize suitable forms of commercial products.
Why granulation is required?
Granulation is a key processing step in the production of many solid dosage drugs. It is often necessary to convert powdered drug formulations into a physical form that has improved flow and compaction characteristics to produce tablets with uniform content and consistent hardness and other properties.
Why is granulation important in tableting?
Granulation process is an inevitable step in tablet manufacturing as it improves flow property and compressibility of powder mass intended for compression. Granulation prevents segregation of the constituents of the powder mix.
Which mixture is used for wet granulation process?
Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent which can be removed by drying, and should be non-toxic. Typical solvents include water, ethanol and isopropanol and methylene chloride either alone or in combination.
What is the principle of RMG?
Working principle of RMG: Rapid mixture granulator works on agitation, tumbling. The impeller is responsible for uniformly mixing wet granules and copper helps in a break or reduced particle size.
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10 Reasons To Buy A Tablet (And 5 Reasons Not To)
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Granules formed are relatively more spherical than the powders and have better flow properties. 2. Improved compressibility of powders resulting from wet granulation process allows the use of low pressure during compression. This reduces machine wear and thus improves the life of the machine.
Why are tablets still made using wet granulation?
The dissolution rate of tablets manufactured by wet granulation may decrease with aging. In spite of all these limitations, the manufacture of tablet using wet granulation still persist due to the following reasons: a. Availability of extensive data on manufacture of existing products by wet granulation.
What are the steps in the wet granulation process?
Steps involve in Wet granulation 1. Mingling of Excipients & Drugs. 2. Mixing of powder with binder solution. 3. Granular sieving of wet mixture. 4. Drying of soggy granules. 5. Sifting of dry granules.
What kind of liquid is used for wet granulation?
1. Wet Granulation: 2. Wet Granulation: • Method in which the powder particles mix can be done by the use of granulating liquid. • Volatile solvent is used as a granulating liquid. GRANULATING LIQUIDS: • Ethanol. • Isopropanol & water (used individually or in the combination).
