What medication is given for tumor lysis syndrome?

What medication is given for tumor lysis syndrome?

In general, treatment of TLS consists of intensive hydration, stimulation of diuresis, and, more specifically, in the use of allopurinol and rasburicase.

What are the most common cancers that pose a risk of TLS upon treatment?

Patients with a large “tumor burden” of cancer cells and/or tumors that typically have rapidly dividing cells, such as acute leukemia or high-grade lymphoma, as well as tumors that are highly responsive to therapy, are at greatest risk of developing TLS.

What causes spontaneous tumor lysis syndrome?

Spontaneous tumor lysis syndrome is a rare oncological emergency associated with multiorgan failure. It is characterized by an elevation of uric acid, hyperphosphatemia, hypocalcemia, hyperkalemia and renal failure in the setting of no active chemotherapy as a result of lysis of massive tumor burden.

What do you do for tumor lysis?

All patients who are at risk for the tumor lysis syndrome should receive intravenous hydration to rapidly improve renal perfusion and glomerular filtration and to minimize acidosis (which lowers urine pH and promotes the precipitation of uric acid crystals) and oliguria (an ominous sign).

Can you have tumor lysis syndrome without chemo?

Tumor lysis syndrome (TLS) presenting in absence of chemotherapy is a rare occurrence. One of the true oncological emergencies, it can lead to significant morbidity and mortality. TLS is a phenomena usually associated with tumor cell death after treatment.

What happens with tumor lysis syndrome?

The tumor lysis syndrome occurs when tumor cells release their contents into the bloodstream, either spontaneously or in response to therapy, leading to the characteristic findings of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia.

Why is tumor lysis syndrome an emergency?

Tumor Lysis Syndrome (TLS) is an oncologic emergency due to massive tumor cell lysis, characterized by metabolic abnormalities that can lead to renal failure, seizures, and dysrhythmia.