What is interstitial nephritis?
What is interstitial nephritis?
Interstitial nephritis is a kidney disorder in which the spaces between the kidney tubules become swollen (inflamed). This can cause problems with the way your kidneys work.
What causes TINU syndrome?
Infection as a risk factor for TINU In general, infection is thought to be a much less common cause of acute TIN than drug-induced disease. A number of case reports have linked TIN to viral infections including hantavirus, cytomegalovirus, Epstein-Barr virus (EBV), polyoma (BK) virus, adenovirus and HIV.
What is the most common type of uveitis present in patients with TINU syndrome?
Most patients with TINU experience a bilateral sudden-onset anterior uveitis which presents with typical symptoms of redness, pain and photophobia.
Is interstitial nephritis life threatening?
Interstitial nephritis is a serious condition, but it can be treated. In rare cases, it may cause kidney failure. When the kidneys fail, waste and extra fluid build up in the body.
Can interstitial nephritis be cured?
Chronic tubulointerstitial nephritis has no cure. Some patients may require dialysis. Eventually, a kidney transplant may be needed.
What infections cause interstitial nephritis?
Infections with viral agents, bacteria, and fungi are occasionally associated with acute interstitial nephritis. Hantavirus, cytomegalovirus (CMV), and human immunodeficiency virus (HIV) are common among the infectious agents associated with acute interstitial nephritis.
Is interstitial nephritis reversible?
The infection-induced and idiopathic types of acute interstitial nephritis were always reversible. Drug-related acute interstitial nephritis caused permanent renal insufficiency in 36% with a maximum of 56% in NSAID-induced cases.
Can Tinu be cured?
Patients with TINU syndrome have been treated successfully with corticosteroids14), but the use of systemic steroids may be restricted in patients with significant tubulointerstitial injury. However, uveitis must be treated because of its poor prognosis.
Is Iridocyclitis and uveitis the same thing?
When the inflammation is limited to the iris, it is termed iritis. If the ciliary body is also involved, it is called iridocyclitis….Background.
| Type | Primary Site of Inflammation | Manifestation |
|---|---|---|
| Anterior uveitis | Anterior chamber | Iritis/iridocyclitis/anterior cyclitis |
Can you cure interstitial nephritis?
Treatment for interstitial nephritis depends on the cause. When AIN is caused by a drug allergy, the only treatment needed may be drug removal. Other cases of AIN can be treated with anti-inflammatory medications. Quick treatment often leads to a full recovery.
What drugs can cause interstitial nephritis?
Acute interstitial nephritis is an immune process that is most commonly caused by penicillins, diuretics, allopurinol, nonsteroidal anti-inflammatory drugs, cimetidine, and sulfonamides. Prompt recognition of the disease and cessation of the responsible drug are usually the only necessary therapy.
How is chronic interstitial nephritis treated?
Chronic tubulointerstitial nephritis is treated by stopping the causative drug or treating the underlying disorder. Supportive care such as controlling blood pressure is often used. Drugs may be used to try to slow progression of kidney disease.
What is the syndrome of tubulointerstitial nephritis with uveitis?
2 Department of Pathology, University of Massachusetts Medical School, Worcester, MA. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a multisystemic autoimmune disorder that may occur in response to various environmental triggers, including drugs and microbial pathogens.
Which is inflammation of renal interstitium and uveal tissue?
Inflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected.
Which is part of the body is implicated in uveitis?
The eye is commonly implicated, with a spectrum of uveitis manifestations including anterior, intermediate, posterior or panuveitis with granulomatous or non-granulomatous features. Kidney involvement is less frequent, with 20% having granulomatous interstitial nephritis]
Which is a rare disease, Tinu or uveitis?
Prevalence: TINU is a relatively rare disease, accounting for less than 1-2% of all patients presenting to ophthalmology. It is also a small percent of patients with a first episode of acute non-granulomatous anterior uveitis. The true prevalence is unknown and probably higher due to undiagnosed cases labeled idiopathic.
