Does amiodarone affect sodium levels?

Does amiodarone affect sodium levels?

Hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) during amiodarone therapy is a rare but potentially lethal adverse effect of this drug. We describe the lowest reported serum sodium level due to amiodarone therapy.

Can amiodarone cause SIADH?

Conclusion: SIADH-induced hyponatremia associated with amiodarone occurs rarely. Since severe hyponatremia is associated with significant neurological damage and mortality, clinicians should carefully monitor serum sodium during amiodarone therapy.

Does amiodarone lower sodium?

Amiodarone prolongs the myocardial action potential and refractory period by affecting the sodium, potassium, and calcium channels. It is used in the treatment of various cardiac arrhythmias, including ventricular tachycardia, ventricular fibrillation, atrial fibrillation, and supraventricular tachycardia.

Does amiodarone affect prostate?

To date, there have been no cases of prostate involvement with amiodarone usage. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer and is the most commonly used serum marker for prostate cancer.

Can amiodarone raise PSA levels?

Similarly, deposition of amiodarone and its metabolite might occur in the prostate gland and this leads to lipidosis and ultrastructural changes seen in other organs, and this may lead to secretion of PSA.

Does caffeine affect PSA test?

Can alcohol or coffee consumption skew results? Alcohol and caffeinated drinks are not established risk factors for prostate cancer and will not affect PSA levels.

What are the long-term side effects of amiodarone?

Amiodarone is a lipophilic structure with a half-life of 25-100 days. Long-term oral amiodarone is associated with photosensitivity, thyroid dysfunction, and pulmonary and hepatic toxicity. Intravenous amiodarone can lead to sweating, heating sensation, nausea, phlebitis at the injection site, and r …

Are there any cases of amiodarone induced irreversible hepatotoxicity?

One patient with amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, showed a reversible course of liver function and imaging after discontinuation of amiodarone.

Where does amiodarone accumulate in the human body?

Amiodarone is highly lipophilic and is concentrated in many tissues and cells, including hepatocytes in the liver. It has a slow onset of action and a long but variable elimination half life (up to 6 months) and can accumulate in tissues including hepatocytes.

How often should a patient with amiodarone be monitored?

Monitoring Patients treated with amiodarone should be followed regularly to assess ongoing need for amiodarone, efficacy of the drug, appropriateness of dosage, adverse effects, and potential drug interactions.