Is there an alternative to docetaxel?

Is there an alternative to docetaxel?

An alternative to docetaxel containing regimens are paclitaxel regimens The ECOG 1199 trial in which 4988 patients with stage 2 or 3A breast cancer (node positive or high risk node negative were randomised to receive 4 cycles of AC followed by either i) 4 cycles of paclitaxel 175 mg.

Is there an alternative to Taxotere?

“These results suggest that weekly nab-paclitaxel may be an appropriate alternative to docetaxel (Taxotere) in the first-line treatment of patients with metastatic breast cancer,” Gradishar said.

Why is dexamethasone used with docetaxel?

Background: The administration of docetaxel requires the use of dexamethasone for the prevention of hypersensitivity reactions (HSRs) and fluid retention reactions (FRRs). The manufacturer recommends dexamethasone for 3 days starting the day before docetaxel.

When do you withhold docetaxel?

Patients who are dosed initially at 75 mg/m2 and who experience either febrile Reference ID: 3101735 Page 7 neutropenia, neutrophils <500 cells/mm3 for more than one week, severe or cumulative cutaneous reactions, or other grade 3/4 non-hematological toxicities during Docetaxel Injection treatment should have treatment …

How bad is docetaxel?

Docetaxel may cause severe lack or loss of strength, which can last a few days up to several weeks. Tell your doctor if you unusual tiredness or weakness. This medicine contains alcohol and may cause some people to become drowsy, dizzy, or less alert than they are normally.

Is docetaxel a strong chemo?

Because the active ingredient, docetaxel, is a strong chemotherapy drug, it also has a long list of side effects. Most of them are typical for drugs in this class, such as nausea, vomiting and temporary alopecia (hair loss).

How bad is Taxotere?

Low white blood cell counts, also called neutropenia, can occur in people who take Taxotere. A more serious version accompanied with fever is called febrile neutropenia. Sometimes, it can be serious enough to cause an infection that requires hospitalization.

Which is worse Taxol or Taxotere?

According to an article recently published in the Annals of Oncology, longer follow-up results indicate that the chemotherapy agent Taxotere® (docetaxel) remains superior to the chemotherapy agent Taxol® (paclitaxel) in the treatment of metastatic breast cancer among patients who have received prior therapy with …

How toxic is docetaxel?

Cutaneous toxicity Docetaxel is also known to cause a skin toxicity known as acral erythema. It often starts with a tingling sensation in the palms and soles, followed by tenderness and edema. Occasional desquamation and blistering in the affected area may also occur.

Is Taxotere a strong chemo?

Because Taxotere is a strong chemotherapy drug, its side effects tend to be more extreme than drugs that treat less serious issues such as high cholesterol or blood pressure. Doctors may lower the dose or prescribe drugs that reduce the risk of allergic reactions to deal with these types of side effects.

How long after docetaxel Will I feel better?

Your muscles or joints may ache or become painful two to three days after you have your treatment. This usually wears off after a few days to a week but may last a bit longer for some people.

Is Taxotere a strong chemo drug?

How often should I take dexamethasone before taking docetaxel?

75 mg/m2 IV on day 1 and cyclophosphamide 600 mg/m2 IV on day 1, given every 21 days for 4 cycles (TC regimen). Premedicate with dexamethasone 8 mg by mouth twice daily for 3 days, beginning 1 day prior to docetaxel administration, to reduce the incidence and severity of fluid retention and hypersensitivity reactions.

How often can I take capecitabine before docetaxel?

75 mg/m2 IV on day 1 plus capecitabine (1,250 mg/m2 by mouth twice daily on days 1 to 14) as a 21-day cycle. Premedicate with dexamethasone 8 mg by mouth twice daily for 3 days, beginning 1 day prior to docetaxel administration, to reduce the incidence and severity of fluid retention and hypersensitivity reactions.

Is it safe to premedicate docetaxel with corticosteroids?

However, docetaxel treatment is still associated with hypersensitivity reactions and fluid retention. Therefore, premedication with corticosteroids are used to minimize these risks, but the optimal steroid dosage for a weekly docetaxel regimen remains unclear. For the study, investigators analyzed data from 206 patients undergoing weekly docetaxel.

When to give loratadine as a premedication for docetaxel?

Due to lower incidence and severity of docetaxel HSRs after steroid treatment, histamine antagonists are not routinely given as premedication, however some clinicians still choose to administer a H1-antagonist such as loratadine 10 mg PO, 60 minutes prior to the docetaxel infusion.