Does CellCept have a black box warning?
Does CellCept have a black box warning?
The labeling of CellCept, taken to prevent the rejection of transplanted organs, has been revised to state that miscarriage and congenital malformations have been associated with its use. The drug labeling now contains a black box warning indicating the change to a Pregnancy Category D.
What strengths does CellCept come in?
MYCOPHENOLATE MOFETIL (CELLCEPT) The medicine comes in 250 mg and 500 mg tablets. The standard dose is 1000 mg twice a day. Some people need a higher dose of 1500 mg twice a day.
How do you interpret mycophenolate levels?
Mycophenolic acid glucuronide (MPA-G) levels in the range of 35 to 100 mcg/mL indicate that the patient has normal uridine diphosphate glucuronosyltransferase (UGT) metabolic capacity. MPA-G levels are typically in the range of 100 to 250 mcg/mL during the 2 weeks following transplantation.
What is mycophenolate mofetil 500 mg used for?
Mycophenolate is used in combination with other medications to keep your body from attacking and rejecting your transplanted organ (such as kidney, liver, heart). It belongs to a class of medications called immunosuppressants.
Is CellCept well tolerated?
Mycophenolate mofetil is safe, well tolerated, and preserves lung function in patients with connective tissue disease-related interstitial lung disease. Chest.
How long does it take for CellCept to be absorbed?
Mycophenolate mofetil is rapidly absorbed in the small intestine. The maximum concentration of its active metabolite, MPA, is attained 60 to 90 minutes following an oral dose. The average bioavailability of orally administered mycophenolate mofetil in a pharmacokinetic study of 12 healthy patients was 94%.
Does CellCept lower your immune system?
CELLCEPT weakens the body’s immune system and affects your ability to fight infections. Serious infections can happen with CELLCEPT and can lead to hospitalizations and death. These serious infections can include: Viral infections.
Why do you have to take CellCept on an empty stomach?
Taking mycophenolate with food may help to lessen stomach cramping and diarrhea. Food affects how the body absorbs mycophenolate. To keep the blood levels of mycophenolate the same, you should always take it the same way, either with food or without food.
What should I monitor with CellCept?
Patients receiving CellCept should be monitored for neutropenia. Neutropenia has been observed most frequently in the period from 31 to 180 days post-transplant in patients treated for prevention of kidney, heart and liver rejection.
What is a normal tacrolimus level?
Most individuals display optimal response to tacrolimus with trough whole blood levels of 5.0 to 15.0 ng/mL. Preferred therapeutic ranges may vary by transplant type, protocol, and comedications.
Does Cellcept lower your immune system?
What happens if you take Cellcept with food?
How many milligrams of CellCept should I take?
The recommended dose of CellCept oral suspension is 600 mg/m2 administered twice daily (up to a maximum daily dose of 2 g/10 mL oral suspension). Patients with a body surface area of 1.25 m2 to 1.5 m2 may be dosed with CellCept capsules at a dose of 750 mg twice daily (1.5 g daily dose).
How often should I take CellCept for liver transplant?
The recommended dose of CELLCEPT for adult liver transplant patients is 1.5 g administered orally twice daily (daily dose of 3 g) or 1 g infused intravenously over no less than 2 hours, twice daily (daily dose of 2 g).
What are the side effects of taking CellCept capsules?
Patients should avoid inhalation or contact of the skin or mucous membranes with the powder contained in CellCept capsules and oral suspension. If such contact occurs, they must wash the area of contact thoroughly with soap and water. In case of ocular contact, rinse eyes with plain water.
What should I do if I miss a dose of CellCept?
Do not stop taking this medication or change the dose without consulting your physician. Capsules or tablets of CellCept should be swallowed whole, not crushed or opened. It is important that other people not be exposed to CellCept powder. If you miss a dose and remember it within 12 hours, take the missed dose as soon as you remember.
