How does isoniazid cause peripheral neuropathy?
How does isoniazid cause peripheral neuropathy?
Second, INH inhibits the enzyme pyridoxine phosphokinase; this enzyme is necessary to activate pyridoxine to pyridoxal 5′ phosphate, the cofactor in many “pyridoxine-dependent” reactions. Functional pyridoxine deficiency is the likely mechanism of INH-induced peripheral neuropathy.
How do you prevent peripheral neuropathy from isoniazid?
The present report gives results which show that the B-complex preparation is fully effective in preventing peripheral neuropathy in patients receiving the same high dosage of isoniazid, and that this is due to the small pyridoxine content of only 6 mg daily, and not to any of its other constituents.
Is isoniazid peripheral neuropathy reversible?
Isoniazid though a very effective treatment for tuberculosis can cause severe motor-dominant neuropathy which can be reversible with pyridoxine supplementation.
Can isoniazid cause nerve damage?
Peripheral neuropathy is a rare adverse effect associated with isoniazid, and it occurs after the prolonged use of this drug [1]. This usually presents with paresthesias which can be accompanied by muscle aches, occasionally muscular weakness, and can progress to more severe symptoms such as ataxia [1].
Can TB cause peripheral neuropathy?
Peripheral neuropathy (PN) is a serious condition affecting the nerves that is commonly seen in patients with tuberculosis (TB).
Why is Vit B6 given with isoniazid?
Isoniazid can interfere with the activity of vitamin B6. Vitamin B6 supplementation is recommended, especially in people with poor nutritional status, to prevent development of isoniazid-induced peripheral neuritis (inflamed nerves). One case is reported in which injectable vitamin B6 reversed isoniazid-induced coma.
Which vitamin prevents the side effects of isoniazid?
Your doctor may also direct you to take vitamin B6 (pyridoxine) to help prevent certain side effects (such as nerve problems) from isoniazid.
How does isoniazid cause peripheral neuropathy in adults?
The isoniazid-induced peripheral neuropathy occurring in adult tuberculous patients results from a deficiency of biologically active pyridoxine. The deficiency is caused by the combination of isoniazid and pyridoxine to form a hydrazone which is excreted in the urine.
What do you mean by drug induced peripheral neuropathy?
In this MiniReview, the term ‘drug-induced peripheral neuropathy’ (DIPN) is used with the suggested definition: Damage to nerves of the peripheral nervous system caused by a chemical substance used in the treatment, cure, prevention or diagnosis of a disease. Optic neuropathy is included in this definition.
Is there a link between isoniazid and pyridoxine?
The deficiency is caused by the combination of isoniazid and pyridoxine to form a hydrazone which is excreted in the urine. It can be prevented by administration of pyridoxine whenever isoniazid is given. A 10 mg.
What are the side effects of isoniazid oral syrup?
For Healthcare Professionals. Applies to isoniazid: intramuscular solution, oral syrup, oral tablet. The most commonly reported side effects included mild and transient elevation of serum transaminase levels, peripheral neuropathy, and hepatitis.
