Is osteomalacia a cancer?

Is osteomalacia a cancer?

The majority of tumors that cause oncogenic osteomalacia are small and slow-growing. These tumors most commonly occur in the skin, muscles, or bones of the extremities or in the paranasal sinuses around the head. Most of these tumors are benign, meaning they are not associated with cancer .

What causes Tio?

TIO is caused by tumors that produce too much of a protein called fibroblast growth factor 23 (FGF23), which controls the balance of phosphorus in the body.

What is oncogenic osteomalacia?

Oncogenic osteomalacia — also referred to as tumor-induced osteomalacia (TIO) — is a rare endocrine disorder in which a small bony or soft tissue mesenchymal tumor causes hypophosphatemia via secretion of FGF23 .

What is Hypophosphatemic osteomalacia?

Hypophosphatemic osteomalacia (HO) is an uncommon metabolic disease characterized by low concentrations of serum phosphate levels, which leads to reduced mineralization of the bone matrix (1). It may affect individuals of all ages and either gender.

Can osteomalacia be cured?

If you have osteomalacia – the adult form of rickets that causes soft bones – treatment with supplements will usually cure the condition. However, it may be several months before any bone pain and muscle weakness is relieved. You should continue taking vitamin D supplements regularly to prevent the condition returning.

Is osteomalacia genetic?

It’s rare, but some people have a genetic condition that causes osteomalacia.

What is the prognosis for osteomalacia?

Osteomalacia is treatable, usually with vitamin and/or mineral supplements, and most people can be cured. It is generally treated by administration of vitamin D, calcium and, if needed, also phosphorus. If the osteomalacia is caused by an underlying condition, this will also need to be treated.

How is osteomalacia treated?

Treatment for osteomalacia involves providing enough vitamin D and calcium, both required to harden and strengthen bones, and treating disorders that might cause the condition.

Is osteomalacia an autoimmune disease?

Many disorders are associated with osteomalacia. The leading causes are nutritional and intestinal diseases. Occasionally, renal tubule disorder results in impaired vitamin D metabolism and can be complicated by osteomalacia. Primary Sjögren syndrome (SS) is an autoimmune disorder affecting primarily exocrine glands.

Can osteomalacia be inherited?

This disorder may be acquired or genetic and follow autosomal recessive inheritance. Bone symptoms include rickets in children and softening of bones (osteomalacia) in adults.

Are there any medical treatments for hypophosphatemia?

Medical Care. Oral phosphate supplements are also useful for the treatment of possible oncogenic osteomalacia until the time when the tumor can be identified and surgically removed. Oral phosphate supplements are well tolerated except in high doses, which can produce diarrhea.

Are there any oral phosphate supplements for osteomalacia?

Oral phosphate supplements are also useful for the treatment of possible oncogenic osteomalacia until the time when the tumor can be identified and surgically removed. Oral phosphate supplements are well tolerated except in high doses, which can produce diarrhea.

Are there any new treatments for hypophosphatemic rickets?

Recently, FGF23 antibody treatment has become available for individuals with some genetic forms of hypophosphatemic rickets.The FDA approved the first drug, burosumab (Crysvita), for X-linked hypophosphatemia (XLH) in April 2018.

What kind of Doctor do you see for phosphate wasting?

A nephrologist can help confirm the likelihood of phosphate wasting and can help assess the patient for causes of renal phosphate wasting. A surgeon is required for parathyroidectomy or for removal of a tumor causing oncogenic osteomalacia.