What does it mean when your lipoprotein is high?
What does it mean when your lipoprotein is high?
High levels of Lp(a) can create plaque in your blood vessels. This is a buildup of cholesterol that lessens blood flow through your arteries. A high level of Lp(a) can be a sign of cholesterol-related disease, such as coronary artery disease. Research has found it to be an independent risk factor for heart disease.
How is high lipoprotein A treated?
The best treatment for LP(a) is to reduce the cholesterol burden of the particle with a statin which will shrink the particle size. A new injectable treatment known as an anti-sense therapy which stops LP(a) being made is currently due to start phase 3 clinical research trials.
What medical conditions increase Lipoprotein A?
Premature heart disease or a family history of premature heart. A familial history of high Lp(a). Familial hypercholesterolemia (FH). Recurrent heart disease despite optimal LDL-lowering.
What causes high Lp A?
Besides genetics, Lipoprotein (a) levels may result from increased intake of some types of fats, and some medical conditions. Treatment of elevated Lipoprotein (a) is based on a person’s risk of heart attack or stroke.
How high is too high for lipoprotein A?
Everybody should have their Lp(a) concentration measured once in their lifetime. CVD risk is elevated when Lp(a) concentrations are high i.e. > 50 mg/dL (≥100 mmol/L). Extremely high Lp(a) levels >180 mg/dL (≥430 mmol/L) are associated with CVD risk similar to that conferred by familial hypercholesterolemia.
How serious is FH?
FH is a serious disorder. If left untreated, FH leads to premature heart disease. Yet for most people with FH, until they experience a heart attack, there are few physical signs or symptoms.
What should my serum sodium level be in a liter?
Somewhere around 135 to 145 milliequivalents per liter, or mEq/L, is the ideal range for serum sodium, reports MedlinePlus. It isn’t common for sodium levels to be low, but once your sodium drops below 135 mEq/L, it can be problematic. Having a level of 125 milliequivalents per liter or less is severely dangerous.
What causes low serum sodium in the blood?
It helps regulate blood pressure and is needed for proper muscle and nerve cell functioning. Low serum sodium, or hyponatremia, is the term used to describe sodium levels in the blood lower than 135 mmol/L on a basic metabolic panel. Common causes are burns, diarrhea, excessive sweating,…
Which is the most common form of LPA?
The most common LPA form known in research is described as 18:1 oleoyl-LPA (1-acyl-2-hydroxy-sn-glycero-3-phosphate). There are different LPA species depending on the acyl chain length and so their molecular mass can vary between 430 and 480 Da.
What is the role of LPA in the central nervous system?
This review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.
