What is a PVL infection?
What is a PVL infection?
PVL-positive Staphylococcus aureus (PVL-SA) causes recurrent skin and soft tissue infections (SSTIs), but can also cause invasive infections, including necrotising haemorrhagic pneumonia in otherwise healthy young people in the community.
Does clindamycin inhibit PVL toxin production?
Indeed, several studies have reported the ability of clindamycin at sub-MICs to decrease the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) [1–6].
Is PVL carried by all MRSA?
Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen associated with nosocomial and community infections. Panton Valentine leukocidin (PVL) is considered one of the important virulence factors of S….
| Specimen type | Total number of MRSA | PVL positive (%) |
|---|---|---|
| Body fluids | 2 | 0 |
How does clindamycin reduce toxin?
Clindamycin acts by inhibiting bacterial protein synthesis at the level of the 50S ribosome. As a result, it exerts a prolonged postantibiotic effect. It may decrease toxin production and increase microbial opsonization and phagocytosis even at subinhibitory concentrations.
How do you get rid of PVL staph?
How can PVL-SA be treated? cut in the skin with a sterile instrument and allowing the pus to drain from the abscess or boils. ➢ Antibiotic treatment is not normally required for minor infections. ➢ Incision and drainage of abscesses.
How did MRSA get the PVL gene?
PVL is mostly associated with community-acquired methicillin-resistant S. aureus (MRSA) infections and distinguishable from nosocomial MRSA by nonmultidrug resistance and carriage of the type IV staphylococcal chromosome cassette element (SCCmec type IV) (6,7).
What kind of toxin is Panton Valentine leukocidin?
Panton–Valentine leukocidin (PVL) is one of many toxins associated with S. aureus infection. Because it can be found in virtually all CA-MRSA strains that cause soft-tissue infections, it was long described as a key virulence factor, allowing the bacteria to target and kill specific white blood cells known as neutrophils .
Where did the name Valentine leukocidin come from?
It was initially discovered by Van deVelde in 1894 due to its ability to lyse leukocytes. It was named after Sir Philip Noel Panton and Francis Valentine when they associated it with soft tissue infections in 1932.
How can you tell if Clindamycin has inducible resistance?
In these cases, clindamycin may have inducible resistance that could emerge on therapy, so the laboratory can perform a double-disc diffusion test to check for inducible resistance and determine true susceptibility. 15
