What is MEN1?

What is MEN1?

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary condition associated with tumors of the endocrine (hormone producing) glands. MEN1 was originally known as Wermer syndrome. The most common tumors seen in MEN1 involve the parathyroid gland, islet cells of the pancreas, and pituitary gland.

What is a symptom of Zollinger-Ellison syndrome?

Zollinger-Ellison syndrome is a rare digestive disorder that results in too much gastric acid. This excess gastric acid can cause peptic ulcers in your stomach and intestine. Symptoms include abdominal pain, nausea, vomiting, weight loss, and diarrhea.

How do you rule out Zollinger-Ellison syndrome?

How Is Zollinger-Ellison Syndrome Diagnosed? If your doctor suspects that you have ZES, they will perform a blood test to look for high levels of gastrin (the hormone secreted by gastrinomas). They may also perform tests to measure how much acid your stomach is producing.

How serious is MEN1?

MEN 1 is a rare condition. It has been estimated that it affects between 1 in 10,000 to 1 in 30,000 people. The same number of men and women are affected. The age at which people with MEN1 start to develop tumours is variable and is not predictable based on the family history.

When should you suspect Zollinger-Ellison syndrome?

A medical professional may suspect Zollinger-Ellison syndrome if blood drawn after the infusion shows an elevated gastrin level. Once a diagnosis is made, localizing the tumor is important. Most Gastrinoma are small lesions and therefore, localizing the tumor may be difficult.

Is Zollinger-Ellison syndrome curable?

Outlook / Prognosis The condition can be cured if the gastrinoma is successfully removed with surgery. If surgery is not possible, in some cases Zollinger-Ellison syndrome can be managed medically. People with Zollinger-Ellison syndrome can live active lives for many years after diagnosis.

When should you suspect gastrinoma?

The diagnosis of gastrinoma may be suspected in patients with stomach or small intestinal ulcers if they: are resistant to treatment. have recurrent ulcers. have associated complications such as intestinal perforation and bleeding.

How does Zollinger Ellison syndrome cause gastrinoma?

Medical researchers are still studying the exact cause of Zollinger-Ellison syndrome. About 25 to 30 percent of Gastrinoma’s are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 (MEN1).1 MEN1 causes hormone-releasing tumors in the endocrine glands and the duodenum.

How is Zollinger Ellison syndrome related to men 1?

Association with MEN 1. Zollinger-Ellison syndrome may be caused by an inherited condition called multiple endocrine neoplasia, type 1 (MEN 1). People with MEN 1 also have tumors in the parathyroid glands and may have tumors in their pituitary glands. About 25 percent of people who have gastrinomas have them as part of MEN 1.

What are the symptoms of gastrinoma type 1?

About 25 to 30 percent of Gastrinoma’s are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 (MEN1).1 MEN1 causes hormone-releasing tumors in the endocrine glands and the duodenum. Symptoms of MEN1 include increased hormone levels in the blood, kidney stones, diabetes, muscle weakness, weakened bones, and fractures.

How are gastrinomas related to peptic ulcers?

Most gastrinomas manifest with peptic ulcer symptoms, but some patients present with diarrhea. About half of patients have multiple gastrinomas and about half have multiple endocrine neoplasia syndrome; half of gastrinomas are malignant.